| Product name: |
ErbB-2/HER-2 Mouse mAb |
| Alternative Names: |
CD340, HER 2/neu, HER2, MLN 19, MLN19, NEU, NGL, p185, p185erbB2, Proto oncogene c ErbB 2, Proto oncogene Neu, TKR1 |
| Source: |
Mouse |
| Applications: |
WB, IHC |
| Reactivity: |
Human, Rat, Mouse |
| Dilutions: |
WB 1:2,000-4,000 IHC 1:200 |
| Immunogen: |
Synthetic Peptide |
| Storage: |
PBS with 0.02% sodium azide and 50% glycerol pH 7.4.
Store at -20°C. Avoid?repeated?freeze-thaw?cycles. |
| Clonality: |
Monoclonal |
| Isotype: |
IgG1 |
| Concentration: |
1mg/ml |
| Observed Band: |
138kDa |
| GeneID（Human）: |
2064 |
| Human Swiss-Prot No: |
P04626 |
| Cellular localization: |
Cytoplasm. Nucleus and Cell membrane |
| Background: |
ErbB 2 is a receptor tyrosine kinase of the ErbB 2 family. It is closely related instructure to the epidermal growth factor receptor. ErbB 2 oncoprotein is detectable in a proportion of breast and other adenocarconomas, as well as transitional cell carcinomas. In the case of breast cancer, expression determined by immunohistochemistry has been shown to be associated with poor prognosis.
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